What's That Rash?

As we age, levels of a vital molecule called nicotinamide adenine dinucleotide (NAD+) decline. Could reversing this be the key to eternal youth?
There’s huge interest in NAD-boosting supplements like nicotinamide mononucleotide (NMN). But is there good evidence that they can help us live longer, healthier?
Norman and Tegan unpack how NAD+ became the focus of anti-aging proponents.
This episode first aired on November 4, 2024.
References:
NAD+ metabolism and its roles in cellular processes during ageing
NAD+ in Brain Aging and Neurodegenerative Disorders
What is really known about the effects of nicotinamide riboside supplementation in humans
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
The use of a systems approach to increase NAD+ in human participants
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Shift workers make a lot of sacrifices to keep the world running. What are they sacrificing in terms of their own health?
There are harms associated with working at all hours against your body clock.
Norman and Tegan work through what those are, and what you can do to protect against them.
References:
5 long-term health effects of shift work
Shift work can harm sleep and health: What helps?
Coping with shift work
Shift work and health outcomes: an umbrella review of systematic reviews and meta-analyses of epidemiological studies
Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses
Relationship between long-term shift work; night work; sleep deficiency and stroke: A systematic review and meta-analysis
Shifting Rhythms: A Systematic Review Exploring the Multifaceted Effects of Shift Work and Circadian Disruption on Employee Cardiovascular Health
Exercise interventions for sleep and cognitive dysfunction in shift workers: a systematic review of randomized trials 
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Chronotypes: early birds vs night owls
Why do some people pee more often?

When you're done with your weekly grocery shop, how colourful is your trolley?
We know eating lots of fruits and vegetables is good for you, but colour could matter.
Norman and Tegan discuss what gives fruit and veggies their hue and whether it's important when it comes to healthy eating.
References:
Phytonutrients: Paint your plate with the colours of the rainbow
Clinical Evidence of the Benefits of Phytonutrients in Human Healthcare
Eat a Rainbow – Nutrition Australia
Phytochemicals: Principles and Practice
What’s the Difference Between Sweet Potatoes and Potatoes?
Role of Phytonutrients in the Prevention and Treatment of Chronic Diseases: A Concrete Review
Major phytochemicals, their sources, active sites, and the related health benefits
Effect of Fruit and Vegetable Consumption on Human Health: An Update of the Literature
Adding variety to your diet lowers disease risk. But what does variety mean?
Which Colour of Bell Pepper Has Most Nutrients? 
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Should you be eating more fruit?
Why Norman won't shut up about the Mediterranean diet
What are the health benefits of coffee?

How much time does your oral hygiene routine take? You brush, floss, interdent, maybe even use a tongue scraper.
Is using a mouthwash going to give you any additional benefit? Or could you be doing some harm?
Norman and Tegan answer questions about the effectiveness of mouthwash, what it does to your oral microbiome and why there might be a link to blood pressure.
References:
Oral microbiome: Unveiling the fundamentals
Effectiveness of Mouthwashes in Managing Oral Diseases and Conditions: Do They Have a Role?
Effect of Adjunctive Use of Commercial Daily Mouthwashes on Periodontal Health: An Umbrella Review
Effect of post-brushing mouthrinse solutions on salivary fluoride retention
Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?
Effects of chlorhexidine and a polyherbal mouthwash on the oral microbiome and user satisfaction: a randomized controlled trial
The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence?
Oral hygiene, mouthwash usage and cardiovascular mortality during 18.8 years of follow-up
Does Mouthwash Use Affect Oral Cancer Risk? A Comprehensive Systematic Review and Meta-Analysis
An update on mouthwashes: advice for dental practitioners 
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Can flossing benefit more than your teeth?
How risky is sharing a toothbrush?
Should you opt for aluminium-free deodorant?

Continuous glucose monitors, or CGMs, have transformed how people with diabetes manage their blood sugar.
But in wellness circles, more and more people without diabetes are being encouraged to try these devices.
Norman and Tegan get to the bottom of what these devices can actually tell you, and the potential harms.
References:
The wellness inspired rise of continuous glucose monitors for people without diabetes, including those with metabolic disorders – BMJ features
Continuous glucose monitoring in non-diabetic populations: a systematic review of observational and interventional studies with meta-analysis 
Blood glucose monitoring devices: current consideration – Australian Prescriber
The Use of Continuous Glucose Monitoring to Diagnose Stage 2 Type 1 Diabetes
Associations of continuous glucose monitor derived time in range and glycaemic variability with diet lifestyle and demographics
Different Glucose Variability in Women With Polycystic Ovary Syndrome With and Without Insulin Resistance: A Pilot Study
Understanding the benefits and psychological burdens of using continuous glucose monitoring for lifestyle change: A mixed-methods cross-sectional study
Unintended Consequences: The Intersection of Diabetes Technology and Disordered Eating Risk 
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