American Journal of Psychiatry Audio

• April 2025: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis

  Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:32     Mancini interview 02:26     Anticholinergic burden method of action 02:58     Balancing the impact of side effects in schizophrenia treatment 04:52     Limitations 05:34     The need for further studies 05:59     Clinical implications 06:32     Further research 07:01     Trials needed 07:54     Kalin interview 08:03     Mancini et al. 11:23     Tiihonen et al. 13:43     Zhou et al. 16:28     Omlor et al. 18:51     Orhan et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

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• March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials

  Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:45     Horan interview 03:15     Novel mechanism of action in the treatment of schizophrenia 05:39     Side effect profiles 07:20     Clinical impacts 08:31     The need for further investigation 09:58     Limitations 11:05     Further research 13:08     Kalin interview 13:21     Horan et al. 17:34     Levenstein et al. 19:00     Fountoulakis et al. 20:57     Couture et al. 23:18     Stern et al. 27:35     McGirr et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

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• February 2025: Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders

  Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction. 00:35     King interview 00:45     Allostatic model of addiction 02:12     Gathering data and the groups studied 07:37     The ethics of studying alcohol use in patients with AUD 10:38     Findings 13:29     The impacts of alcohol’s pleasurable effects on people with AUD and those without 14:32     Limitations of natural environment research versus laboratory research 18:18     Clinical implications 20:09     Further research 22:56     Kalin interview 23:03     King et al. 26:21     Brand et al. 28:12     Conway et al. 32:17     Kypriotakis et al. 35:42     Kuhn et al. 39:37     Grilo et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

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• January 2025: Special Issue on Psychedelics

  Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment. 00:38     Nemeroff interview 02:27     McIntyre et al. 04:06     Ramaekers et al. 05:44     Ghaznavi et al. 08:01     Fonzo et al. 09:17     Wolfgang et al. 10:45     Psychedelics and psychotherapies 12:31     Aaronson et al. 14:17     Pagni et al. 15:31     Kirlić et al. 17:06     Olson Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

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• December 2024: Discrimination Exposure, Neural Reactivity to Stress, and Psychological Distress

  Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP. 00:36     Grey and Knight interview 02:41     Demographics of the cohort 03:46     Neurobiological mechanisms of discrimination impacts 06:14     Racial discrimination and mental health impacts 09:34     Discrimination as a chronic stressor and prolonged activation of the stress response system 10:45     Limitations 13:52     Further research 14:38     Kalin interview 14:52     Grey et al. 17:35     Sippel et al. 18:06     Fox and Shackman 19:42     Kliemann et al. 22:16     Kamboj et al. 27:07     Pathak et al. Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

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