A Chat with Anat

• Monitoring the fellow eye in nAMD

  My guest for this special episode is Professor Paolo Lanzetta, Chair of the Department of Ophthalmology at the University of Udine, Italy. In this episode, Paolo and I explore the importance of monitoring the fellow eye of patients with nAMD. We also discuss methods and techniques for early detection of disease, the difference in monitoring for patients with DME, and the Vision Academy’s evidence-based guidance on monitoring the fellow eye. To learn more about monitoring the fellow eye in patients with nAMD, read the Vision Academy Viewpoint, the Vision Academy slide deck, and the Vision Academy publication on current concepts and modalities for monitoring the fellow eye in nAMD.  For more information about patient-focused care, visit the nAMD Barometer and DR Barometer websites.If you enjoyed this episode, SUBSCRIBE to “A Chat with Anat” to make sure you never miss an episode! Speaker disclosures:Professor Anat LoewensteinConsultant: 4DMT, AbbVie, Astellas, Bayer, Beyeonics, Eyepoint, Notal Vision, Ocular Therapeutix, Ocuphire, Oculis, Opthea, Roche, Boehringer-Ingelheim, Aviceda, VoiantProfessor Paolo LanzettaConsultant: Aerie, Allergan, Apellis, Bausch + Lomb, Bayer, Biogen, Boehringer Ingelheim, I-Care, Genentech, Novartis, Ocular Therapeutix, Outlook Therapeutics, and Roche May 2025 PP-PF-OPHT-ALL-0219-1Further information on topics discussed in this podcast:Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T; ANCHOR Study Group. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology. 2009 Jan;116(1):57─65.e5.Chew JK, Zhu M, Broadhead GK, Luo K, Hong T, Chang AA. Bilateral Neovascular Age-Related Macular Degeneration: Comparisons between First and Second Eyes. Ophthalmologica. 2017 Jan 1;238(1-2):23–30.Downey L, Acharya N, Devonport H, Gale R, Habib M, et al. Treatment choices for diabetic macular oedema: a guideline for when to consider an intravitreal corticosteroid, including adaptations for the COVID-19 era. BMJ Open Ophthalmol. 2021 Apr 27;6(1):e000696.Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY; MARINA StuThis podcast series is intended for HCPs, and is not intended for UK audiences. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. This podcast series is produced and funded by Bayer. The views and opinions expressed throughout this podcast are the speakers' own, based on their clinical experience and expertise.The Barometer Program is managed by clinical leaders in ophthalmology as well as representatives from the IFA, IAPB and Bayer. The activities of the Barometer Program are funded and facilitated by Bayer where the scientists and representatives from IFA and IAPB retain decision authority to the research scope, methods, analysis of findings, and dissemination of the outputs of the Barometer Program. The Vision Academy is a group of over 80 international experts who, through their collective expertise, provide consensus guidance for managing clinically challenging situations, especially in areas of controversy or with insufficient conclusive evidence. The Vision Academy is funded and facilitated by Bayer. The opinions and guidance of the Vision Academy outputs are those of its members and do not necessarily reflect the opinions of Bayer.

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• Choosing the right regimen for patients with nAMD

  My guest for this special episode is Prof. Jean- François Korobelnik from the Department of Ophthalmology at the University Hospital, and at CHU Bordeaux, in Bordeaux, France. In this episode, Jean-François and I explore the importance of choosing the right regimen for our patients with nAMD. We discuss the evidence we can gather from clinical trials, and the lessons we learn from patients we see during clinical practice. We also explore the algorithm developed by the Vision Academy to choose the best regimen for patients.To learn more about how to choose the best treatment regimens to optimize outcomes for patients with nAMD, read the Vision Academy Viewpoint, and the accompanying slide deck. Please also visit the Vision Academy website. For more information about patient-focused care, visit the nAMD Barometer and DR Barometer websites.If you enjoyed this episode, SUBSCRIBE to “A Chat with Anat” to make sure you never miss an episode! Speaker disclosures:Professor Anat LoewensteinConsultant: 4DMT, AbbVie, Astellas, Bayer, Beyeonics, Eyepoint, Notal Vision, Ocular Therapeutix, Ocuphire, Oculis, Opthea, Roche, Boehringer-Ingelheim, Aviceda, Voiant.Professor Jean- François KorobelnikConsultant: Abbvie, Adverum, Apellis, Bayer, Boehringer-Ingelheim, Carl Zeiss Meditec, Eyepoint Pharma, Ocular Therapeutix, Roche, SeaBeLife, Thea; member of the data safety monitoring board or advisory board for Alexion, Novo Nordisk, and Opthea.April 2025 PP-PF-OPHT-ALL-0215 -1Further information on topics discussed in this podcast:Teo KYC, Eldem B, Joussen A, Koh A, Korobelnik JF, Li X, Loewenstein A, Lövestam-Adrian M, Navarro R, Okada AA, Pearce I, Rodríguez F, Wong D, Wu L, Zur D, Zarranz-Ventura J, Mitchell P, Chaudhary V, Lanzetta P. Treatment regimens for optimising outcomes in patients with neovascular age-related macular degeneration. Eye (Lond). 2024. doi: 10.1038/s41433-024-03370-0. Gemenetzi M, Patel PJ. A Systematic Review of the Treat and Extend Treatment Regimen with Anti-VEGF Agents for Neovascular Age-Related Macular Degeneration. Ophthalmol Ther. 2017;6:79-92. Arnold JJ, Campain A, Barthelmes D, Simpson JM, Guymer RH, Hunyor AP, McAllister IL, Essex RW, Morlet N, Gillies MC; Fight Retinal Blindness Study Group. Two-year outcomes of "treat and extend" intravitreal therapy for neovascular age-related maculThis podcast series is intended for HCPs, and is not intended for UK audiences. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. This podcast series is produced and funded by Bayer. The views and opinions expressed throughout this podcast are the speakers' own, based on their clinical experience and expertise.The Barometer Program is managed by clinical leaders in ophthalmology as well as representatives from the IFA, IAPB and Bayer. The activities of the Barometer Program are funded and facilitated by Bayer where the scientists and representatives from IFA and IAPB retain decision authority to the research scope, methods, analysis of findings, and dissemination of the outputs of the Barometer Program. The Vision Academy is a group of over 80 international experts who, through their collective expertise, provide consensus guidance for managing clinically challenging situations, especially in areas of controversy or with insufficient conclusive evidence. The Vision Academy is funded and facilitated by Bayer. The opinions and guidance of the Vision Academy outputs are those of its members and do not necessarily reflect the opinions of Bayer.

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• Revolutionizing holistic patient care: Innovations and technologies

  My guest for this special episode is Dr. John Kitchens, Vitreoretinal Surgeon with Retina Associates of Kentucky in the USA. In this episode, John and I explore the importance of holistic patient care. We also highlight the latest advances in home monitoring technologies in retinal disease, and how artificial intelligence (AI) can be used to aid in disease monitoring and optimization of clinic organization. To learn more about the current status of AI in screening, diagnosing and managing retinal diseases, read the Vision Academy Viewpoint, and the Vision Academy retinal expert consensuses by clicking here or here. For more information about patient-focused care, visit the nAMD Barometer and DR Barometer websites. If you enjoyed this episode, SUBSCRIBE to “A Chat with Anat” to make sure you never miss an episode! Speaker disclosures:Professor Anat Loewenstein- Consultant: Consultant for 4DMT, Abbvie, Alkeus, Annexon, Apellis, Astellas, Bayer health care, Beyeonics, Eyepoint, J & J, NotalVision, Novartis, Ocular Therapeutics, Ocuphire Pharma, Ocuterra, Oculis, Opthea, Oxurion, Roche, Syneos.Dr. John Kitchens - Consultant: Alcon, Allergan, Alimera, Apellis, Astellas, Bayer, Biogen, Bausch + Lomb, Genentech, Kodiak Bioscience, Notal Vision, Optos, Oculus, Outlook, Regeneron, Roche, and Zeiss. Speaker: Alcon, Bayer, Genentech, and Regeneron. Owns stock in Regeneron.Further information on topics discussed in this podcast:Age-Related Eye Disease Study Research Group. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8. Arch Ophthalmol. 2001;119:1417–1436.The Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew EY, SanGiovanni JP, et al. Lutein/Zeaxanthin for the Treatment of Age-Related Cataract: AREDS2 Randomized Trial Report No. 4. JAMA Ophthalmol. 2013;131:843–850. Anguita R, Ferro Desideri L, Loewenstein A, et al. The digital age in retinal practice. Int J Retina Vitreous. 2024 Sep 26;10:67. doi: 10.1186/s40942-024-00580-2. January 2025 PP-PF-OPHT-ALL-0199-1This podcast series is intended for HCPs, and is not intended for UK audiences. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. This podcast series is produced and funded by Bayer. The views and opinions expressed throughout this podcast are the speakers' own, based on their clinical experience and expertise.The Barometer Program is managed by clinical leaders in ophthalmology as well as representatives from the IFA, IAPB and Bayer. The activities of the Barometer Program are funded and facilitated by Bayer where the scientists and representatives from IFA and IAPB retain decision authority to the research scope, methods, analysis of findings, and dissemination of the outputs of the Barometer Program. The Vision Academy is a group of over 80 international experts who, through their collective expertise, provide consensus guidance for managing clinically challenging situations, especially in areas of controversy or with insufficient conclusive evidence. The Vision Academy is funded and facilitated by Bayer. The opinions and guidance of the Vision Academy outputs are those of its members and do not necessarily reflect the opinions of Bayer.

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• Treatment futility and success in the context of suspending treatment

  My guest for this episode is Professor David Wong from the Department of Ophthalmology and Vision Sciences, University of Toronto and Unity Health Toronto in Toronto, Canada. In this episode, David and I discuss the Vision Academy’s algorithms for suspending treatment for nAMD in the context of treatment futility and success. Our conversation highlights the monitoring considerations and criteria used to define treatment futility and success, and the potential of predictive biomarkers and at-home monitoring to optimize patient follow-up. Important resources, such as the Vision Academy Viewpoint and algorithm on suspending treatment of nAMD in cases of futility, can be found on the website. Or can be downloaded directly from here; view point and slide deck. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. If you enjoyed this episode, SUBSCRIBE to ‘A Chat with Anat’ to never miss an episode! Further information on content in other podcasts in this series can be found here.Speaker disclosures:Professor Anat LoewensteinConsultancy: 4DMT, Abbvie, Alkeus, Annexon, Apellis, Astellas, Bayer health care, Beyeonics, Eyepoint, J & J, NotalVision, Novartis, Ocular Therapeutics, Ocuphire Pharma, Ocuterra, Oculis, Opthea, Oxurion, Roche, Syneos.Professor David Wong Consultancy: Abbvie, Alcon, Apellis, Bayer, Bausch Health, Biogen, Boehringer Ingelheim, Novartis, Ripple Therapeutics, Roche, Topcon, and Zeiss; Research grants: Novartis and Roche.Further information on other studies mentioned in this episode:Wong DT, et al. SUSPENDING TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION IN CASES OF FUTILITY. Retina. 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448759/ June 2024 PP-PF-OPHT-ALL-0162-1'A Chat with Anat' is a series for ophthalmologists who are interested in improving delivery of care and improved outcomes for patients living with neovascular age-related macular degeneration (nAMD). I’m Professor Anat Loewenstein, Chair of the Department of Ophthalmology at Tel Aviv Sourasky Medical Centre in Israel, and Professor of Ophthalmology and Vice Dean at Tel Aviv University. For each episode, I will be joined by internationally renowned colleagues to discuss key topics on patient-focusedThis podcast series is intended for HCPs, and is not intended for UK audiences. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. This podcast series is produced and funded by Bayer. The views and opinions expressed throughout this podcast are the speakers' own, based on their clinical experience and expertise.The Barometer Program is managed by clinical leaders in ophthalmology as well as representatives from the IFA, IAPB and Bayer. The activities of the Barometer Program are funded and facilitated by Bayer where the scientists and representatives from IFA and IAPB retain decision authority to the research scope, methods, analysis of findings, and dissemination of the outputs of the Barometer Program. The Vision Academy is a group of over 80 international experts who, through their collective expertise, provide consensus guidance for managing clinically challenging situations, especially in areas of controversy or with insufficient conclusive evidence. The Vision Academy is funded and facilitated by Bayer. The opinions and guidance of the Vision Academy outputs are those of its members and do not necessarily reflect the opinions of Bayer.

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• World Sight Day and collaboration for change in eye health

  My guest for this special episode is Peter Holland, Chief Executive of the International Agency for the Prevention of Blindness (IAPB). We speak about the importance of World Sight Day, and discuss how different initiatives, such as the Love Your Eyes campaign, have helped put eye health on the global agenda in collaboration with members and partners.We also highlight how clinicians can leverage their voices and influence to share knowledge, shape policies, and strengthen cross-sector collaborations, leading to the development of important resources for patients and clinicians to improve care. We recommend visiting the IAPB’s website, and the websites of the nAMD Barometer Program and Vision Academy for more information on World Sight Day, and resources to help you in your clinic. If you enjoyed this episode, SUBSCRIBE to ‘A Chat with Anat’ to make sure you never miss an episode! Speaker disclosures:Professor Anat LoewensteinConsultant: AbbVie, Bayer, Beyeonics, Syneos, Ripple, Iveric Bio, Johnson & Johnson, Ocuphire, Iqvia, Notal Vision, Novartis, and Roche.Peter HollandEmployee: International Agency for the Prevention of Blindness.Further information on topics discussed in this podcast:Child eye health. The International Agency for the Prevention of Blindness. https://www.iapb.org/learn/vision-atlas/magnitude-and-projections/child-eye-health/. Accessed October 9, 2024.October 2024 PP-PFM-OPHT-ALL-0042-1This podcast series is intended for HCPs, and is not intended for UK audiences. Always refer to local treatment guidelines and relevant prescribing information. Please review the product information before prescribing. This podcast series is produced and funded by Bayer. The views and opinions expressed throughout this podcast are the speakers' own, based on their clinical experience and expertise.The Barometer Program is managed by clinical leaders in ophthalmology as well as representatives from the IFA, IAPB and Bayer. The activities of the Barometer Program are funded and facilitated by Bayer where the scientists and representatives from IFA and IAPB retain decision authority to the research scope, methods, analysis of findings, and dissemination of the outputs of the Barometer Program. The Vision Academy is a group of over 80 international experts who, through their collective expertise, provide consensus guidance for managing clinically challenging situations, especially in areas of controversy or with insufficient conclusive evidence. The Vision Academy is funded and facilitated by Bayer. The opinions and guidance of the Vision Academy outputs are those of its members and do not necessarily reflect the opinions of Bayer.

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