TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Rotavirus viroporin activity, calcium waves, and pathogenesis (Sci Adv) T cells control human orthoflavivirus challenge (Nat Micro) Letters read on TWiV 1189 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – The Perfect Cacio e Pepe Recipe, According to Science (primary article here) Kathy – Dragonflies Loop-the-Loop Alan – My Beloved Monster, by Caleb Carr Vincent – Why Did the FDA Ban Red Dye #3 Listener Picks Anne – Japan’s 65-Foot Towering Snow Walls Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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1:32:45
TWiV 1188: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, trials and devices to relieve some neurological complications of long COVID and the ramifications of long COVID in children, healthcare workers and adults. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode No morbidity and mortality in the US this week? (NPR) More support for Marburg outbreak in Tanzania (Reliefweb) Tanzania confirming second Marburg case (CIDRAP) Norovirus mRNA vaccine …..hmmmm? (moderna) What is noronvirus? (modernatx) Largest tuberculosis outbreak ever in the US (Reuters) Ebola outbreak in DRC during US:WHO strain (STAT News) Uganda Ebola outbreak…..1 dead (Reuters) Polio outside endemic zone due to militants? (Washington Post) Mpox vaccination initiation in central Africa (CIDRAP) Preparing rapid response to emerging infectious disease in Africa (PANTHER Health) Mpox therapeutic study MOSA enrollment begins (Africa CDC) Halting of US foreign aid for health programs…..not in the US best interests? (NY Times) No PEPFAR (NY Times) PEPFAR (US Department of State) PEPFAR…..still not America first? Really? (CIDRAP) Resurgence of infections globally may affect US…..what is global health? (NY Times) Milk testing for H5N1….but I thought raw milk was the only healthy milk? (USDA) How do you like your $10.99 dozen of eggs? (NY Times) Farm outbreak of H5N1 (AP News) US- high pathogenicity avian influenza viruses (World Organization for Animal Health) H5N9 high pathogenic flu in duck farm California (CIDRAP) More egg issues (CIDRAP) Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) RSV: Waste water scan for 11 pathogens (WastewaterSCan) RSV-Network (CDC Respiratory Syncytial virus Infection) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024 (LANCET Infectious Diseases) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long COVID Recovery Program with Zara Dureno, BA, MOT The current and future burden of long COVID in the United States (JID) Transcutaneous vagus nerve stimulation improves Long COVID symptoms in a female cohort (Frontiers in Neurology) Transcutaneous vagus nerve stimulation trials: https://www.mountsinai.org/clinical-trials/tvns-in-long-covid-19 https://www.centerwatch.com/clinical-trials/listings/NCT06585254/tvns-in-long-covid-19 Devices: https://pulsetto.tech/products/meet-pulsetto?pulsetto_offer_id=57&transaction_id=1024e5a0258b6647e262ba8fec5d62 https://www.dolphinmps.com/product/dolphin-neurostim-professional-single-kit-vagal-stim-kit/ Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls (Pediatric Research) Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection(PLoS Medicine) SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York (LANCET: Regional Health Americas) Impact of COVID-19 Pandemic on the incidence and prevalence of postural orthostatic tachycardia syndrome (EHJ-QCCO European Heart Journal-Quality of Care & Clinical Outcomes) Letters read on TWiV 1188 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
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47:49
TWiV 1187: The tau of herpesvirus
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease. Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Entry receptor for EV-D68 (Cell Host Microbe) Anti-herpetic tau preserves neurons in Alzheimers (Cell Rep) Letters read on TWiV 1187 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Good genes are nice, but joy is better Brianne – Beaker Hair Clip Kathy – Pareidolia explained by street artist David Zinn TEDx talk Also visit zinnart.com Alan – Screwworm is coming back in the Americas Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation Listener Picks Sarah – The Extremophile Campaign: In Your Home (ECIYH) citizen science Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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1:56:41
TWiV 1186: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tanzania confirms Marburg virus outbreak (Reuters) Clade Ib mpox in England (Reuters) Withdrawing from the World Health Organization (WhiteHouse) Fees costs behind withdrawing from WHO ….is that what we are suppose to believe? (Sky News) Sorry to see you go, US? (WHO) Where are the updates? (CDC Health Alert Network) Pause in health communications of all kind (Washington Post) NIH chaos…..streaming to a halt? (STAT News) Devastation at the NIH, hiring traveling, meetings, communications(Science) Protect your cat from bird flu (NPR) No communication and cats with bird flu….does not sound good (CIDRAP) Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Baloxavir marboxil for prophylatix against influenza(NEJM) Comparative effectiveness of baloxavir marboxil and oseltamir treatment for reducint household transmission of influenza (Influenza and other respiratory viruses) RSV: Waste water scan for 11 pathogens (WastewaterSCan) RSV-Network (CDC Respiratory Syncytial virus Infection) US respiratory virus activity (CDC Respiratory Illnesses) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Host-microbe multiomic profiling identifies distinct COVD-19 immune dysregulation in solid organ transplant recipients (Nature Communications) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Fusion center near you….if in NY (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19 (Signal Transduction and Targeted Therapy) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long COVID Recovery Program with Zara Dureno, BA, MOT Letters read on TWiV 1186 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
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46:59
TWiV 1185: The birds and the Bs
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 GBS with RSV vaccine (FDA) Increase in respiratory infections in China (ECDC) Elsevier journal editors resign (Retract Watch) Wild bird associated pathogens (Med) Broad anti-neuraminidase antibody (Cell Host Micr) Letters read on TWiV 1185 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Dear Reviewer 2 Rich – National Data Buoy Center Alan – BBC audio program on the World Morse Code Championships Vincent – These are the 20 most-studied bacteria — the majority have been ignored Listener Picks Peter – Local graffiti in Sydney Vivian – The Peoples’ Hospital by Dr. Ricardo Nuila Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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